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Featured in ESPN's Mind Gurus

Research Studies

VeRelief's underlying technology was demonstrated to be safe and effective in over 150 patients across 3 IRB-approved and placebo-controlled clinical studies and one IRB-approved case study.


Dr. Nicholas Hool, Dr. William J. Tyler, Dr. Sarah Wyckoff, and Dr. Taylor Hearn conducted a study aimed at developing a Targeted Neuroplasticity Training (TNT) method to enhance foreign language learning. They focused on optimizing noninvasive vagus nerve stimulation (VNS) techniques that are comfortable and suitable for everyday use in various training environments.

The researchers explored transdermal auricular vagal nerve stimulation (taVNS), which targets nerve fibers in the external ear, as a more comfortable alternative to other methods. They designed biocompatible, hydrogel earbud electrodes for unilateral or bilateral use, and evaluated their safety and efficacy across different frequencies and intensities.

The team also examined the impact of taVNS on autonomic physiology, attention, sensory gating, and plasticity using various measurements, including heart rate, heart rate variability, skin conductance, skin temperature, respiration rate, EEG, and pupillometry.

The study found that the dry, hydrogel earbud electrode design is a safe and effective method for taVNS.

Read the safety and efficacy report for the first prototype study here

View Results



  • 18 competitive golfers during a 150-yard hitting task.


  • 10 minutes of vagus and great auricular nerve stimulation on both sides of neck (bilateral stimulation).


  • 36% Clinically Significant Reduction (36%) in state-anxiety in active treatment group after single 10-min treatment. Only 18% reduction in placebo group.
  • No differences in safety and tolerability between active and placebo treatments (Pain, dizziness, blurred vision, headache, skin itching or irritation).
  • Significant increase in quality of feel of each shot in active group only.

Study Three


  • 24 patients with self-diagnosed Post Traumatic Stress Disorder and Panic Disorder.


  • 5-minutes of VeRelief treatment on each side of the neck for a 10-minute total treatment time.


  • 24% Clinically Significant Reduction in State-Anxiety in active treatment group after single treatment
  • 31% Increase in Heart Rate Variability (rMSSD) in active group alone. 0% change in sham group.
  • 100% Of Active Users reported treatment to be "Relaxing". 33% of sham participants found treatment to be relaxing.
  • Active participants were 2x more relaxed than sham participants.
  • No differences in safety and tolerability between active and sham treatments (Pain, dizziness, blurred vision, headache, skin itching or irritation).


Population: Individual 23-year-old male patient living with diagnosed Panic Disorder and Post-Traumatic Stress Disorder

Protocol: Use 2x per day for 8 weeks. After 8 weeks of using the devices, patient was asked to rate each statement as Strongly Agree, Agree, Neutral, Disagree, or Strongly Disagree.


"I feel better after using the device"

Strongly Agree 63% of the time

Agree 37% of the time

"The device decreases the severity of my symptoms"

Agree 75% of the time

Neutral 25% of the time

"I felt better having access to this device in case I have symptoms"

Strongly Agree 25% of the time

Agree 75% of the time

"The Device is easy to use"

Strongly Agree 12.5% of the time

Agree 75% of the time

"The Device helps me relax"

Strongly Agree 37% of the time

Agree 63% of the time

Patient Statement:

“It has stopped some panic attacks from getting worse and [felt like] I was melting into my bed. Complete mental and physical relaxation.”

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